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Mary Kay Clinical Solutions™ Retinol 0.5

1 fl. oz.

$78.00

Powered by pure, high-concentration retinol, this nighttime serum takes the offensive against wrinkles, discoloration and loss of firmness. Retinol is the gold-standard ingredient dermatologists recommend for adults of every age, and it helps prevent signs of aging you can’t see yet, while helping to reverse advanced visible signs of aging.

Do not use Mary Kay Clinical Solutions™ Retinol 0.5 if you are pregnant, lactating or planning to become pregnant.
This product cannot be shipped to or sold in the Dominican Republic due to local regulations.

All prices are suggested retail.

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  • Overview
  • Application Tips
  • Key Ingredients
  • Awards And Honors
  • Claims and Benefits

Mary Kay Clinical Solutions™ Retinol 0.5

Pure retinol. Pure WOW. Amplify your age-fighting with a dermocosmetic serum powered by pure, potent, high-concentration retinol. (You can’t stop time, but don’t be surprised when consistent nighttime use reveals a level of skin vibrancy you haven’t seen in years!)

Formula Attributes

  • Fragrance-free.
  • Dermatologist-tested.
  • Non-comedogenic.
Clinical Solutions Dermatologist Seal

Dermatologists’ Council Seal

In developing the Mary Kay Clinical Solutions™ line of products, Mary Kay went above and beyond the normal process of safety testing and claims review, providing behind-the-scenes access to an external advisory panel of U.S. board-certified dermatologists to help validate the formula and ingredients. The panel includes dermatologists selected for their extensive skin care expertise, scholarship and professional practice. The panel conducted a thorough review and evaluation of clinical tests, data and/or scientific support for the formula and ingredients.

Application Tips

When using a high-concentration retinol product, it is important to gradually establish skin tolerance, also referred to as "retinization," before advancing to more frequent usage. If you are a first-time user of pure retinol,* Mary Kay’s gentle retinization process (below) is recommended for you.

During the retinization process, Mary Kay recommends avoiding physical and chemical exfoliation products, acne products and products with high concentrations of vitamin C since they may contribute to temporary dryness or irritation.

WEEKS 1 2

Apply Mary Kay Clinical Solutions™ Retinol 0.5 1x per week on the same night, diluted with Mary Kay Clinical Solutions™ Calm Restore Facial Milk.

Directions: In the evening, cleanse skin and wait approximately five to ten minutes. Mix a pea-sized amount (one pump) of Mary Kay Clinical Solutions™ Retinol 0.5 with one pump of Mary Kay Clinical Solutions™ Calm Restore Facial Milk. Apply mixture to forehead, cheeks, nose and chin in an upward, outward motion, avoiding the eye area. Allow for full absorption before applying other skin care products. Mary Kay Clinical Solutions™ Calm Restore Facial Milk can also be used throughout the day and week as needed to relieve skin. Use sunscreen during the day.

WEEKS 3 4

Apply Mary Kay Clinical Solutions™ Retinol 0.5 1x per week on the same night, followed by Mary Kay Clinical Solutions™ Calm Restore Facial Milk.

WEEKS 5 6

Apply Mary Kay Clinical Solutions™ Retinol 0.5 2x per week, followed by Mary Kay Clinical Solutions™ Calm Restore Facial Milk, as needed.

WEEKS 7 8

Apply Mary Kay Clinical Solutions™ Retinol 0.5 3x – 5x per week, followed by Mary Kay Clinical Solutions™ Calm Restore Facial Milk, as needed.

WEEKS 9

Continued benefits come with continued usage. Usage frequency of Mary Kay Clinical Solutions™ Retinol 0.5 is based on skin tolerance. Once skin is retinized, product may be used as often as every evening, followed by Mary Kay Clinical Solutions™ Calm Restore Facial Milk as needed.

Click here to learn more about retinol’s compatibility with other ingredients and Mary Kay® products and to find out if retinol is right for you. Do not use Mary Kay Clinical Solutions™ Retinol 0.5 if you are pregnant, lactating or planning to become pregnant.

*TimeWise Repair® products do not contain pure retinol. TimeWise Repair® products contain an encapsulated, controlled-release retinol that’s not designed to retinize your skin. If TimeWise Repair® products are your only source for retinol, Mary Kay recommends following the retinization process to help skin adjust to the potency of the high concentration retinol found in Mary Kay Clinical Solutions™ Retinol 0.5.
**Results based on an independent expert evaluator assessing 22 women during an eight-week clinical study in which women used Retinol 0.5 every other night for the first two weeks, then applied nightly weeks 3–8.

These products cannot be sold or shipped in the Dominican Republic due to local regulations.

Key Ingredients

Retinol (Vitamin A)

  • Stimulates surface skin cell renewal, so skin appears more like it did when you were younger.
  • Supports natural collagen and elastin, improving the appearance of collagen-depleted skin.

Awards & Honors

We're proud of all of our products and are committed to offering you only the highest-quality, most effective products – so we're very happy when others recognize our products and when our customers agree with us! Here are some of the awards and media mentions for this product.

Shape Beauty Skin Award 2021
Mary Kay Clinical Solutions™ Retinol 0.5

The Mary Kay Clinical Solutions™ Retinol 0.5 has earned the Shape magazine Skin Award 2021. Powered by pure, high-concentration retinol, this nighttime serum takes the offensive against wrinkles, discoloration and loss of firmness. Retinol is the gold-standard ingredient dermatologists recommend for adults of every age, and it helps prevent signs of aging you can’t see yet, while helping to reverse advanced visible signs of aging.
Good Housekeeping Best Beauty Award 2021
Mary Kay Clinical Solutions™ Retinol 0.5

The Mary Kay Clinical Solutions™ Retinol 0.5 has earned the Good Housekeeping magazine Best Beauty Award 2021. Powered by pure, high-concentration retinol, this nighttime serum takes the offensive against wrinkles, discoloration and loss of firmness. Retinol is the gold-standard ingredient dermatologists recommend for adults of every age, and it helps prevent signs of aging you can’t see yet, while helping to reverse advanced visible signs of aging.

Claims and Benefits

In an eight-week independent clinical study of Mary Kay Clinical Solutions™ Retinol 0.5,

  • 100% of women experienced improvement in skin smoothness.
  • 100% of women experienced improvement in skin radiance.

In addition, panelists experienced visible improvement in:

  • Wrinkles
  • Firmness
  • Skin tone evenness

Results based on an independent expert evaluator assessing 22 women during an eight-week clinical study in which women used Mary Kay Clinical Solutions™ Retinol 0.5 every other night for the first two weeks, then applied nightly weeks 3–8. Data reflects the percentage of panelists who showed improvement or the percentage of improvement for an attribute compared to baseline measurements taken at the beginning of the study.