Both Mary Kay Clinical Solutions® boosters next to Mary Kay Clinical Solutions® Retinol 0.5 Set with clear flasks

Mary Kay Clinical Solutions® boosters are dermocosmetic products containing high-concentration ingredients that have been clinically proven for their efficacy. Easily incorporated into an existing skin care routine, they feature meticulously tested ingredients that are scientifically proven to deliver optimal skin care performance. Add them to your already-established skin care routine to target specific skin concerns, such as hydration, lines and wrinkles, skin tone and skin texture.

Take your skin care to new heights with potent, patent-pending Mary Kay Clinical Solutions® boosters. Each booster is comprised of a highly potent dose of scientifically acclaimed skin care ingredients. These easy-to-incorporate formulas are specially designed to beautifully complement your current skin care routine.

  • Mary Kay Clinical Solutions® C + Resveratrol Line-Reducer
  • HA + Ceramide Hydrator
  • Ferulic + Niacinamide Brightener
  • PHA + AHA Resurfacer

Take wrinkle reduction to the next level with Mary Kay Clinical Solutions® C + Resveratrol Line-Reducer for our highest concentrations of vitamin C and resveratrol. As your skin experiences repetitive facial movements, sun exposure, natural aging and other factors, lines and wrinkles can be expected. This targeted solution supports skin with a potent blend of vitamin C, resveratrol and acetyl hexapeptide-8.

The Ingredient Boost

Vitamin C (ascorbic acid)

A heroic antioxidant widely recognized for its ability to fight the visible signs of skin aging, high-concentration vitamin C works around the clock for your skin (when applied morning and night as directed).

  • Vitamin C supports skin’s natural production of collagen and elastin proteins to help improve the look of fine lines and wrinkles.
  • A strong antioxidant, it protects* against the harmful effects of UV- and pollution-induced free radicals on the skin, which can contribute to premature lines and wrinkles. And it’s clinically shown to improve the appearance of lines and wrinkles caused by photodamage.

Similar to vitamin C, resveratrol is a highly potent antioxidant valued not only for its ability to fight visible signs of skin aging but also protect the skin’s surface.

  • Resveratrol supports skin’s natural production of collagen and elastin proteins and helps defend against collagen breakdown.
  • It also helps protect* against photodamage, which can contribute to premature lines and wrinkles.

Acetyl Hexapeptide-8

Skin-restoring acetyl hexapeptide-8 is a special peptide designed to help reduce the appearance of lines and wrinkles.

  • Acetyl hexapeptide-8 helps diminish signals that over time lead to lines and wrinkles.

*Based on in vitro testing

Savor each drop of these powerhouse hydrators in one skin-loving formula. When your skin’s moisture is out of balance, its barrier can become compromised. Support skin’s barrier with Mary Kay Clinical Solutions® HA + Ceramide Hydrator, a unique blend that targets three critical hydration factors.

The Ingredient Boost


Hyaluronic Acid (HA) (sodium hyaluronate)

An increasingly popular powerhouse humectant, hyaluronic acid is known to bind more than 1,000 times its weight in water, meaning it holds onto water molecules to keep skin looking plump and healthy.

Two forms of hyaluronic acid take a dual-action approach to combating dry skin.

  • Low molecular weight HA penetrates the stratum corneum – the outermost layer of the skin – to directly deliver critical moisture and help plump skin from within.
  • High molecular weight HA sits on the skin’s surface to help protect and plump from the outside.


As a critical component of the stratum corneum, ceramide is essential for the retention of skin moisture.

  • Skin-mimicking ceramide helps improve skin hydration and support normal barrier function.


Verbena Officinalis Extract (impacts natural moisturizing factor or NMF)

Increased natural moisturizing factor (NMF) is not only known to improve skin hydration but also skin barrier function – a necessity when it comes to protecting your body from environmental stressors and water loss.

Our chosen plant extract (verbena officinalis) supports skin’s natural production of NMF. NMF components absorb water from the atmosphere and combine with their own water content, allowing the outermost layers of the stratum corneum to stay hydrated despite external factors.


Incorporate these dermatology-inspired ingredients to visibly diminish dark spots. Factors like hormones, aging and pollution can trigger an irregular production of melanin that causes uneven skin tone. Restore your skin’s glowing glory with this triple-threat booster. 

The Ingredient Boost

Ferulic Acid

A high-potency antioxidant, ferulic acid acts like a shield to help defend against external factors that may lead to skin discoloration (hyperpigmentation).

  • Ferulic acid helps prevent free radical formation on the skin, and that means fewer factors that lead to discoloration.
  • It also supports skin’s antioxidant systems* to help reduce discoloration.
  • Its skin-soothing properties help limit key causes of discoloration to reduce the look of uneven skin tone and brighten skin.

Niacinamide (vitamin B3)

One of the best sources of vitamin B3, niacinamide is an essential nutrient that’s been well-recognized globally as a brightening superpower.

  • Niacinamide has been shown to significantly decrease visible skin discoloration (hyperpigmentation) by protecting the skin’s barrier (your first line of defense against aggressors) when applied topically.
  • It also doubles as an antioxidant shown to help limit key causes of discoloration to reduce the look of uneven skin tone and brighten skin.


Navy Bean Extract (vegetable amino acids)

Mary Kay discovered navy bean’s effect on brightening efficacy and patented a proprietary ingredient technology on this discovery.

  • Navy bean extract is shown to significantly improve skin brightness.
  • It also reduces* visible contrast of dark spots and improves the overall appearance of uneven skin tone.


*Based on in vitro testing



Smooth skin and accelerate its renewal with a dynamic, dual-acid boost. As we age, skin cell turnover slows, and that can lead to dull, rough skin. Exfoliation is a must to achieve and maintain smoothness. Gently dissolve dead skin cells while replenishing radiance with this skin routine upgrade.

The Ingredient Boost

Poly-Hydroxy Acid (PHA) (gluconolactone)

The second generation of hydroxy acid technology, PHA has a larger molecular size than alpha-hydroxy acid, meaning it works exclusively on the surface to deliver gentle yet effective exfoliation.

  • Our amount of PHA was specifically chosen so it can be left on skin. It helps improve skin radiance and the appearance of skin texture by breaking apart the bonds between dead skin cells to accelerate exfoliation on the top surface layer of skin.

Alpha-Hydroxy Acid (AHA) (glycolic acid)

With a much smaller molecular size compared to PHA, AHA easily works through the top surface layers of the skin to accelerate deeper exfoliation.

  • AHA helps accelerate skin renewal and exfoliation by breaking apart the bonds between dead skin cells on multiple surface layers.
  • This leave-on acid also helps improve skin radiance and the appearance of skin texture for overall smoothness.



Skin-replenishing glycerin, a natural compound derived from vegetables, serves as the perfect complement to the powerful pairing of two exfoliating hydroxy acids.

  • Glycerin is a widely used humectant due to its ability to attract water to itself and help boost moisture levels on the top layers of skin.


Like a wellness shot for your skin, these dermocosmetic treatments combine concentrated doses of some of science’s most acclaimed ingredients in order to unleash skin’s full potential with every precious drop. Once you’ve determined which booster is right for you, add it seamlessly into your routine.

Dermatologists’ Council seal

Dermatologists’ Council Validation

The Mary Kay Clinical Solutions® boosters feature dermocosmetic formulas that deliver both beauty and dermatological benefits. Whether you’re seeking a visible reduction of fine lines and wrinkles, enhanced hydration or just looking for a way to add more elevated ingredients into your skin care routine, these premium products have you covered.

Hear From Our Scientists.

Get the expert scoop on the dermocosmetic Mary Kay Clinical Solutions® products, including development details and results that deliver.

Amplify your skin care solutions with Mary Kay Clinical Solutions® Retinol 0.5 Set. The gold standard ingredient retinol has been demonstrated to prevent signs of aging that you may not see yet, while the lightweight facial milk has been shown to calm irritated skin and deliver instant hydration.

8 Weeks to Train Your Skin

In this results-focused set, pure, high-concentration retinol pairs wonderfully with a nourishing facial milk

that’s perfect for those incorporating this powerful ingredient into their routine for the first time. Mary Kay has even designed

an 8-week retinization protocol to help minimize potential discomfort that may occur when you first start using pure retinol at

0.5% concentration.

Image of Mary Kay Clinical Solutions® Retinol 0.5 and Mary Kay Clinical Solutions™ Calm + Restore Facial Milk on stairsteps

Weeks 1 + 2: Apply Mary Kay Clinical Solutions® Retinol 0.5 one night per week, diluted with Mary Kay Clinical Solutions® Calm + Restore Facial Milk.

Weeks 3 + 4: Apply Mary Kay Clinical Solutions® Retinol 0.5 one night per week, followed by Mary Kay Clinical Solutions® Calm + Restore Facial Milk.

Weeks 5 + 6: Apply Mary Kay Clinical Solutions® Retinol 0.5 two nights per week, followed by Mary Kay Clinical Solutions® Calm + Restore Facial Milk.

Weeks 7 + 8: Apply Mary Kay Clinical Solutions® Retinol 0. 5 three to five times per week, followed by Mary Kay Clinical Solutions® Calm + Restore Facial Milk.

Use Mary Kay Clinical Solutions® HA + Ceramide Hydrator during the above retinization process to deliver extra moisture to your skin, offsetting any potential increased dryness. Continue using the booster if added hydration is one of your skin goals.

After you’ve completed the retinization process, you can amplify your results by adding Mary Kay Clinical Solutions® C + Resveratrol Line-Reducer to your morning routine, or by alternating evening application with Mary KayClinical Solutions® Retinol 0.5. Or you can choose to incorporate Mary Kay Clinical Solutions® Ferulic + Niacinamide Brightener withMary Kay Clinical Solutions® HA + Ceramide Hydrator.

If your goal is to target texture, see results with Mary Kay Clinical Solutions® PHA + AHA Resurfacer. It is not recommended for you to use Mary Kay Clinical Solutions® Retinol 0.5 with this booster. 

Eight Weeks to Amazing

Mary Kay Clinical Solutions™ Retinol 0.5 takes the offensive against wrinkles, discoloration and loss of firmness and delivers visible improvement. Plus, in an eight-week independent clinical study, 100% of women experienced an increase in skin smoothness and in skin radiance.2